Hi, I have been talking tramodol for over 15 years due to complex back / health issues. Obviously I am completely reliant on these now. I would say if you were going to experience side affects these would show them selves very early on...you can either tolerate them or not....Luckliy I didn't have any side affects at all. Many people can't seem to take them but if you are in extreme pain then definitely worth a try. I wouldn't be able to get out of bed without them. hope this helps you..