There's an old saying "Those that are not with me are against me" so is Merkel thinking/saying that when she said:- "The times in which we could completely depend on others are on the way out. I've experienced that in the last few days. We Europeans truly have to take our fate into our own hands"

Perhaps she realises that the UK and the USA have propped up Europe for  so long and that the good times are now over?

On the other hand, perhaps she's thinking that with the UK and the USA out of the way, now is the time for Germany to dominate European thinking?