Advocate is good for fleas and other parasites like mites and nematodes. A friend of mine uses it on her dogs, but it doesn't claim to be effective against ticks, and her dogs have ticks.

http://www.animalhealth.bayer.com/5723.0.html

Advocate offers:

heartworm prevention
flea and lice treatment and prevention of flea infestations. The product can be also used as part of a treatment strategy for FAD (Flea Allergy Dermatitis)
gastrointestinal worm control including several larval stages
treatment and prevention of lungworms in dogs (Angiostrongylus vasorum and treatment of crenosoma vulpis)
control of ear mites in cats and dogs
control of sarcoptic mange in dogs
control of Demodex mites in dogs